Anti Malarial Bulk Drugs

Quinine Family
Isolated originally from Cinchona succirubra, is a white crystalline alkaloid soluble in alcohol, ether, carbon disulfide, chloroform, and glycerol. It is almost insoluble in water. It is used chiefly (usually in the form of soluble hydrochloride or sulfate salts) in the treatment of falciparum malaria resistant to other antimalarials. Other anti-malaria drugs such as quinacrine, chloroquine, and primaquine are more effective, but murative malarial parasite developed resistance to them.

Artemisinin Family
Qinghaosu ("ching-how-soo") is the active principal of the Chinese medicinal herb Artemisia annua. It has been used as treatment of fevers in China for more than 1000 years. The antimalarial value of Artemisia annua was first documented in Zhou Hou Bei Ji Fang (Handbook of prescriptions for emergency treatments) written as early as 340 AD by Ge Hong of the Eastern Jin Dynasty. The active antimalarial constituent of this plant was isolated in 1971 and it was named artemisinin. The WHO accorded high priority to the development of fast acting artemisinin derivatives for the treatment of cerebral malaria as well as for the control of multi-drug resistant P. falciparum malaria. A water soluble ester called artesunate and two oil soluble preparations called artemether and arteether are available

ARTEMISININ BASED APIs

Artesunate	Alpha- Beta Arteether
Artesunate Sterile Sodium	Dihydroartemisinin
Artemether	Lumefantrine

QUININE BASED APIs & ALKOID EXTRACTS.

Quinine Sulphate USP / EP	Quinine Dihydrochloride USP/ EP
Quinine Hydrochloride USP/ EP	Quinine Bisulphate EP/ USP

QUININE ALKOIDS